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Frequently Asked Questions: Radiation

  1. What is ionizing and non-ionizing radiation?
  2. How does radiation cause health effects?
  3. How do we know radiation causes cancer?
  4. Is diagnostic radiation a major issue?
  5. Is it true that using mammography before age 40 can cause more harm than good?
  6. What does CT stand for and how does it work?
  7. What is the purpose of the CT scan?
  8. What risks are associated with whole body CT scans?
  9. What is being done to reduce radiation exposure?
  10. How concerned should we be about radiation in medicine?
  11. What is the future outlook of harm to the population due to radiation?
  12. How harmful are CT scans for children?
  13. Is the amount of radiation needed to produce a clear image in CT scans the same for children and adults?
  14. Is it true that with the increased use of medical radiation, the incidence of some cancers has actually decreased?
  15. If radiation exposure is so harmful, why do physicians order imaging examinations so frequently?
  16. What efforts have professional societies taken to publicize the risks of inappropriate use of diagnostic radiation?


What is ionizing and non-ionizing radiation?

Radiation that has enough energy to move atoms in a molecule or cause them to vibrate, but not enough to remove electrons, is referred to as non-ionizing radiation. Examples of this kind of radiation are sound waves, visible light, and microwaves. Radiation that can remove electrons is called ionizing radiation, because it has enough energy to remove tightly bound electrons from atoms, thus creating ions and damaging DNA. This is the type of energy that most people think of as radiation. Ionizing or x-ray radiation can be used to ease bone pain for cancer patients, to cause cancerous tumors to die or shrink, to detect fractures, broken bones and to find tumors. Ionizing radiation is also used to produce what is called nuclear energy and in many manufacturing processes.

Adapted from Unknown, (2007, October 3). Ionizing and non-ionizing radiation. Retrieved October 24, 2007, from U.S. Environmental Protection Agency Web site.

How does radiation cause health effects?

Radioactive materials that decay spontaneously produce ionizing radiation, which can strip electrons from atoms or break some chemical bonds, including those involved in the basic building block of all living material—our DNA. Any living tissue in the human body can be damaged by ionizing radiation. We all have the capacity to repair DNA damage, although sometimes that repair capacity cannot work well. Mistakes made in the natural repair process can lead to cancerous cells. The most common forms of ionizing radiation are alpha and beta particles, or gamma and X-rays. Other long-term health effects associated with ionizing or x-ray radiation include birth defects or teratogenic (an agent affecting the embryo or fetus) that include smaller head or brain size, poorly formed eyes, abnormally slow growth, and mental retardation, and genetic mutations passed from parent to child.

How do we know radiation causes cancer?

We have learned through observation of people who have been highly exposed. As the use of radioactive materials and reports of illnesses became more frequent, scientists began to notice patterns in the illnesses. People working with radioactive materials and x-rays developed particular types of uncommon medical conditions. Scientists began to keep track of the health effects, and soon set up careful scientific studies of groups of people who had been exposed. The best known long-term studies are those of Japanese atomic bomb blast survivors, other populations exposed to nuclear testing fallout, and uranium miners.

Is diagnostic radiation a major issue?

According to the American College of Radiology white paper, in the United States, we receive as much radiation from diagnostic procedures every year as was released through the Chernobyl accident, which spewed hundred of Hiroshimas into the environment. The American College of Radiology is calling for a summit meeting with emergency room physicians to come up with ways to reduce unnecessary diagnostic radiation.

E. Stephen Amis, Priscilla F. Butler, Kimberly E. Applegate, et al., “American College of Radiology White Paper on Radiation Dose in Medicine,” Journal of the American College of Radiology 4 (2007): 272-284.

Is it true that using mammography before age 40 can cause more harm than good?

Along with public health experts in Canada, England, and Scandinavia, and famed surgeon Dr. Susan Love, many believe that mammography screening of women who have no symptoms helps to save lives of women who are age 50 and older who are close to menopause. Lately, mammographic screening has been done on younger women and can carry two risks. One is the risk of unnecessary surgery and the fear that goes along with it. The other risk is the radiation itself.  Radiation to the young breast is a risk, as we know from the girls who were preteens at the time of the Hiroshima bombing that now have a much higher risk of breast cancer when they get to be in their 40s and 50s.

Halicks, Richard, Fighting the wrong war: We know what causes cancer, so why don't we attack it there? (2007, September 30). The Atlanta Journal-Constitution.

What does CT stand for and how does it work?

CT stands for computer tomography. In traditional medical diagnostic x-ray equipment, low doses of x-rays are passed through tissues in the body onto a series of detailed cross-sectional images. In CT, the x-rays are targeted through the particular internal part of the body of interest at many hundreds of angles for every cross sectional slice. The information from these x-rays after they have passed through the body is analyzed by a computer, which then creates a series of detailed cross-sectional images. Thus, a typical CT scan can involve dozens to hundreds of chest x-rays.

What is the purpose of the CT scan?

CT scans look at the whole body and are used as a means of screening for early signs of illness in people who have no symptoms or disease risk factors. The benefit is that diseases such as cancer can be treated more successfully if they are detected in their early stages. They are most useful in the examination of specific target organs in the body using a narrow beam of x-rays. It is also used to measure the size and precise location of tumors; to elevate the extent of cancer spread, and as an aid to guiding biopsies and radiation treatments.

What risks are associated with whole body CT scans?

Although CT imaging may be useful as an investigative tool for some potentially fatal disease, general whole body CT scanning in otherwise healthy individuals can also have negative consequences. For example, patients who receive a clean bill of health after a whole body scan may be left with a false sense of security about their health, discouraging them from adopting healthier lifestyles, having regular medical check ups or other more appropriate screening tests. On the other hand, people whose scans produce suspicious findings, such as those often found in the thyroid may be subjected to expensive, invasive and sometimes unnecessary follow-up medical procedures.

What is being done to reduce radiation exposure?

The National Council on Radiological Protection and Measurement is developing a set of guidelines on the management of patient dose in CT scanning. The FDA is developing a tutorial on the dangers associated with CT scanning and it will be available on their website when it is completed. The American Society of Radiologic Technologists has supported the introduction of legislation in the US House of Representatives (HR 583, the Consistency, Accuracy, Responsibility and Excellence in Medical Imaging and Radiation Therapy Act, known as the CARE bill [PDF] ) [50] as a means of providing safer medical imaging examinations by setting federal standards for personnel who perform them. This bill specifically requires certification, licensure, testing, training, or experience for individuals who will be involved in performing medical imaging services.

E. Stephen Amis, Priscilla F. Butler, Kimberly E. Appelgate, et al., “American College of Radiology White Paper on Radiation Dose in Medicine,” Journal of the American College of Radiology 4 (2007): 272-284.

How concerned should we be about radiation in medicine?

In a 2007 white paper on radiation in medicine, the American College of Radiology noted that in the past quarter century, the amount of radiation the U.S. population receives each year from medical imaging has increased fivefold. A single computerized scan of the stomach today can give half the dose that was shown to induce cancer in those who survived the atomic bomb blasts in Japan.

What is the future outlook of harm to the population due to radiation?

A group of Yale researchers, looking at current patterns estimates that in one year, 700 people will die from cancers associated with head CTs and 1,800 will die from radiation-induced cancer from abdominal examinations carried out when they were infants.

Davis, Devra (2007, September 30). Tumor has it. Retrieved October 23, 2007, from New York Post Web site.

How harmful are CT scans for children?

A CT scan to the head of a baby can give you between 200 and 4,000 chest X-rays at once. Therefore, they should be used in a much more limited way.

Mieszkowski, Katharine (2007, October 08). Life will kill you. Retrieved October 23, 2007, from Salon.Com Website.

Is the amount of radiation needed to produce a clear image in CT scans the same for children and adults?

No. The amount of radiation needed to produce a clear image is directly proportional to the subject’s body size. Therefore, children require much less ionizing radiation than adults do when they get X-rays and CT scans. A child, who receives a CT scan for his or her abdominal region using a setting that is meant for adults, ends up being exposed to as much radiation as is used in about 4,000 X-rays. This translates to approximately eight times the amount of ionizing radiation that an adult would be exposed to for a similar procedure.

Adapted from Kim, Ben (2006, December 6). Understanding the potential dangers of CT scanning. Retrieved October 24, 2007, from Dr. Ben Kim: Experience Your Best Health Web site.

Is it true that with the increased use of medical radiation, the incidence of some cancers has actually decreased?

No. Lung cancer is decreasing in men because of smoking cessation and breast cancer is leveling off. There is no evidence that increased screening is responsible for this decline, nor is there any reason to suppose that it could account for the decline in lung cancer . Radiation-induced cancers typically do not occur until 1 or 2 decades after exposure. Therefore, any increase in cancer occurrences due to medical exposure in the past two decades may not be evident for many years to come.

If radiation exposure is so harmful, why do physicians order imaging examinations so frequently?

Although some referring physicians are very knowledgeable regarding radiation safety and incorporate it into their imaging decisions, others have had little or no training in radiation exposure and do not routinely consider this factor when referring for these exams. In addition, non –physician health care providers may be granted the authority to order imaging studies and their ordering patterns may be reflected by the behavior of their supervising physicians.

Amis, E.S., Butler, P.F., Applegate, K.E., Birnbaum, S.B., Brateman, L.F., Hevezi, J.M., Mettler, F.A., Morin, R.L., Pentecost, M.J., Smith, G.G., Strauss, K.J., & Zeman, R.K. (2007). American college of radiology white paper on radiation dose in medication. Journal of    the American College of Radiology. 4, 272-284.

For additional information, review this article by Brenner and Hall on CT scans.
-Brenner DJ, Hall EJ. Computed tomography–an increasing source of radiation exposure. N Engl J Med. 2007;357(22):2277-2284.

What efforts have professional societies taken to publicize the risks of inappropriate use of diagnostic radiation?

For more than a decade, the FDA and professional radiology groups such as the American College of Radiology have provided a number of advisories that warn of the dangers of inappropriate radiation.

Table 1: Chronology of Seminal Guidelines and Actions
Year Organization Document Conclusions
1987
ATSDR, HHS

Toxicological Profile for Ionizing Radiation

Ionizing radiation has toxicologic, adverse health effects.

1987
National Commission on Radiological Protection
NCRP Report on Ionizing Radiation

Medical X-rays and nuclear medicine make up 79% of all manmade exposure, and 15% of all exposure.

1990

National Research Council, National Academy of Sciences, Committee on Biological Effects of Ionizing Radiations (BEIR)

Health Effects of Exposure to Low Levels of Ionizing Radiation: BEIR V

Large epidemiologic studies are needed to verify risk estimates largely based on A-bomb survivors and animal studies.

Especially women and children, both of whom are more sensitive.

1993
 

International Commission on Radiological Protection

National Council on Radiation Protection and Measurements. Limitation of exposure to ionizing radiation. Bethesda, Md: National Council on Radiation Protection and Measurements; 1993. NCRP Report No. 116.

Expect 8% increase in fatal cancer risk per sievert of exposure at a given time. A linear no-threshold model should be used unless proven wrong.

1993
American College of Radiology
AJR Article
Appropriateness Criteria
1996
NRC/NAS
Radiation in Medicine (To Err is Human)

NAS publication

Institute of Medicine. To err is human: building a safer health system.

Washington, DC: National Academy of Sciences; 1999.

Regulatory reform is needed; “only 10% of ionizing radiation used in medicine is subject to NRC and Agreement State regulatory system… Because no federal requirement exists for data collection ... realistic, accurate data on the incidence and type of problems … remain elusive.”[p120]

Public and expert perception of risk diverge
1996
USDoJ
Diagnostic Imaging in Child Abuse
Head

All infants and children suspected of intracranial injury must undergo CT and/or MRI. CT is accepted method for intracranial injury and is key to Dx of shaken baby syndrome.

Speed, availability and lower cost make CT commonly used. MRI is often preferable to CT, among other reasons because more sensitive in imaging subarachnoid hemorrhaging and no ionizing radiation.

Thoracoabdominal trauma
CT examination is indicated.
1999
ATSDR/HHS
Comprehensive 438 pp profile and guidelines
 

Updates 1987 profile with sections on pediatric exposure and new literature. Ionizing radiation is a hazardous substance.

Medical uses account for 15% of exposure. 3m diagnostic examinations on 109,000 x-ray machines in the US in 1989. CT an emerging trend.

2000

United Nations Scientific Committee on Effects of Atomic Radiation

UNSCEAR 2000 Report, Vol I and II, Sources and Effects of Ionizing Radiation

Linear no threshold holds.

Even the smallest dose has the potential to cause a small increased risk.

2000
American Radium Society
President’s address
 
Hall 2000

Single micron beam experiments show bystander effects and mutations when cytoplasm irradiated. Though findings are not yet definite, such experiments will provide data on low levels not measurable in epidemiologic studies and provide missing mechanism data.

2001
Aug 18-19
Society for Pediatric Radiology
 
(funded by GE)
ALARA Conference
**Pediatr Radiol 2002

**Most comprehensive expert discussion of the complex issues and practical guidelines to date

As Low As Reasonably Achievable
*how to determine effective dose
*how to educate others

On individual level risk is outweighed by benefit.

Children are more sensitive by 10x.
Girls more sensitive.

Incidence is greater than mortality. Excess mortality is a public health issue.

There is no consensus regarding single expression of dose.

Only CT for appropriate indications. [10-30% are not]

Adjust (weight) for children.

Manufacturers need to provide tools to prevent excess doses.

More research is needed for dose reduction versus image quality.

Disseminate information to GPs, pediatricians, ER MDs. Educate medical students.

2001
Sept.
Food and Drug Administration

Public Health Notification: Reducing Radiation Risks from Computed Tomography for Pediatric and Small Adult Patients

Recommendations to radiologists, radiation health professionals, risk managers, hospital administrators:

optimize CT settings
reduce multiple scans with contrast material
eliminate inappropriate referrals
2002
National Cancer Institute/NIH &
Society of Pediatric Radiology
Radiation & Pediatric Computed Tomography

Children are more sensitive to radiation and have longer to live than adults.

Minimizing radiation exposure will reduce the projected number of CT-related cancer deaths

Immediate
perform only when necessary
adjust parameters for pediatric use
minimize multi-phase scans
Longer Term
encourage development and adoption of pediatric protocols
educate and disseminate re concerns
research to determine relationship between CT scans and cancer risks
 
2002

National Council on Radiation Protection and Measurements

2-day symposium on CT dose
Linton and Mettler, 2003

70% of all medical doses are now by CT, which is 15% of examinations

Children receive higher doses than they should. These can be reduced without loss of diagnostic information

educate physicians and radiologic technologists
develop technique charts
develop automated exposure control devices
create climate of demand for these when ordering equipment
USE THE SAME LANGUAGE for dose
accreditation is voluntary
2002
American College of Radiology

Large studies are under way to determine whether targeted organ screens save lives.

There is no evidence that total body CT screening is cost efficient or effective in prolonging life.

2005
International Commission on Radiation Protection

Cellular process evidence supports “the view that in the low dose range up to a few tens of mSv, it is scientifically reasonable to assume that in general and for practical purposes cancer risk will rise in direct proportion to absorbed dose in organs and tissues.”

2005
NIEHS

Press Release: US Department of Health and Human Services, Public Health Service, National Toxicology Program. Report on carcinogens. 11th ed.

Ionizing radiation is a known human carcinogen
2005

American Medical Association Council on Science and Public Health

Resolution 521 (A-05), introduced by the Washington Delegation and adopted at the 2005 AMA Annual Meeting

Work with the public health, radiology, and radiation oncology specialty societies and all other interested parties to study the issue of radiation exposure by the American public and develop a plan, if appropriate, to allow the ongoing monitoring and quantification of radiation exposure sustained by individual patients in medical settings.

2006

FDA and Conference of Radiation Control Program Directors (CRCPD)

Nationwide Evaluation of X-Ray Trends
2000 Computed Tomography

Random sample of 265 facilities surveyed in 39 states. Estimates 124 CT procedures/week per facility, of which 93.9% (116) are performed on adults and 6.1% (8) on children.

Estimating total facilities=7,167, that gives 57,336 procedures/week on children or ~3 million/year and 831,372 procedures/week on adults or 43,231,344/year

Children: 65% on head, 33.3% on body
Adults: 41% head, 56% body

Wide variability in exposure for same type of exam.

Recommends adjusting protocol when doses exceed “national norms”

That is, standard is de facto defined as norm.
2006

National Research Council, National Academy of Sciences, Committee on Biological Effects of Ionizing Radiations (BEIR)

BEIR VII Phase 2**
**Considered the definitive source
The balance of all evidence favors a linear no-threshold risk model.
Hormesis rejected based on studies of A-bomb survivors.
Low dose defined as ≤100 mSv
Risk varies higher for females and young at time of exposure.

a single population dose of 10 mSv is associated with a lifetime attributable risk for developing a solid cancer or leukemia of 1 in 1000.

No epidemiologic study of populations exposed to CT was available to the committee.

Studies of prenatal exposure to diagnostic X-rays have provided important information on the existence of a significantly increased risk of leukemia and childhood cancer following diagnostic doses of 10–20 mGy in utero.

Research needs:

Most studies of medical radiation should rely on exposure information collected prospectively, including cohort studies as well as nested case-control studies.

Future studies should continue to include individual dose estimation for the site of interest, as well as an evaluation of the uncertainty in dose estimation.

 

Epidemiologic studies of the following exposed populations would be particularly useful:

follow-up studies of persons receiving CT scans, especially children; and

2.studies of infants who experience diagnostic exposures related to cardiac catheterization, those who have recurrent exposures to follow their clinical status, and premature babies monitored for pulmonary development with repeated X-rays.

2006

American Medical Association Council on Science and Public Health

Directives adopted by the AMA House of Delegates at the 2006 AMA Annual Meeting

1. Collaborate with specialty medical societies and other interested stakeholders to convene a meeting to: (a) examine the feasibility of monitoring and quantifying cumulative radiation exposure sustained by individual patients in medical settings; and (b) discuss methods to educate physicians and the public on the appropriate use and risks of low linear energy transfer radiation  in order to reduce unnecessary patient exposure in the medical setting.

2. The AMA will continue to monitor the National Academy of Sciences’ ongoing efforts to study the impact of low levels of low linear energy transfer radiation on human health.

In addition to the directives, AMA recommends consulting the ACR Appropriateness Criteria.

2006
IARC, NCI/NIH, others
Cancer consequences of Chernobyl

Cardis et al  J. Radiol. Prot. 26(2006) 127–140

Thyroid cancer increased dramatically among exposed in childhood and adolescence. Only 20 years have passed so too early to evaluate full impact, but no other clearly demonstrated increases in cancer risk.

Provides summary of case-control and cohort studies.

2007
American Academy of Pediatrics
Guidance for the Clinician
 
Brody et al.

“Any estimated risk of a CT scan is far less than the likely benefit to the patient for indicated examinations.”

Those exposed at the age of 10 have about 1.0-1.8 times the estimated risk as those exposed at 30.

 

No published studies have directly attributed cancer to CT scanning and it is important to recognize how difficult it would be to perform such a study. The lifetime risk of fatal cancer in the general population is approximately 1 in 5. To perform a study to detect an increase from 0.20 to 0.2002 (plus the 1-in-5000 potential risk from a CT scan) would require hundreds of thousands to millions of subjects and extremely careful matching of the subjects to ensure an accurate result.”

 

Tell patients [...] “Radiologists are specialists in CT who are trained to use the least amount of radiation necessary.”

2007
American College of Radiology
White Paper on Radiation Dose in Medicine*
 

*Major impact on dissemination to specialty associations

 
Amis et al. 2007

Individual benefits “certainly exceed the risks” but “significant increase in the population’s cumulative exposure to ionizing radiation. Will this cause an increased incidence of cancer years down the line? Although the answer to that question is currently under debate, the presumption is that it will.”

CT use has increased from 3 m in 1980 to 60m in 2005

Recommends accreditation

Issues specific recommendations for referring physicians, radiologists, technologists, patients, medical physicists, vendors, regulatory agencies, accrediting bodies and third-party payers.

Should refer to “estimated exposure” not “exposure.”

Jan 22 2008
Alliance for Radiation Safety in Pediatric Imaging Launched
Imagegently.org
(7,400,000 individual members)

Click here for more information.

72,000,000 CTs in 2006—20% up from 60,000,000 in 2005—of which 4,000,000 are pediatric scans.

Recommends promoting understanding of importance of “child-size” radiation doses.